IN THIS EPISODE:
LDL Particles Are Not All the Same
It’s essential to understand that not all LDL particles are created equal. LDL stands for low-density lipoproteins and plays a crucial role in transporting cholesterol and fats throughout the body. However, high levels of LDL, especially small, dense particles, can increase the risk of cardiovascular diseases like atherosclerosis, heart disease, and strokes. As functional practitioners, it is important to understand this in order to tailor approaches for every individual.
Particle Size Matters
The size and density of LDL particles matter when assessing cardiovascular risk. Smaller, denser LDL particles are more atherogenic and susceptible to oxidation, making them more harmful than larger, buoyant particles. These small particles are associated with higher triglyceride levels and often observed in individuals with insulin resistance and metabolic syndrome.
Comprehensive Assessment Is Key
Standard lipid panels, which measure cholesterol, LDL, HDL, and triglycerides, are not enough to assess cardiovascular risk fully. Functional practitioners should consider advanced lipid panels that include particle size and number, assess for oxidized LDL, and examine Lp(a) lipoprotein. Lifestyle factors, such as diet, exercise, and stress management, play a significant role in influencing LDL particle characteristics and should be addressed to reduce cardiovascular risk.
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