Unraveling the Histamine Puzzle with Functional Medicine

IN THIS EPISODE:

Histamine Intolerance

This refers to a condition where individuals experience adverse reactions to histamines in the body. Histamine intolerance can manifest as symptoms such as migraines, nasal congestion, hives, insomnia, and difficulty tolerating fermented foods. 

Histamine intolerance occurs when the body is unable to break down histamine efficiently due to a deficiency in enzymes like diamine oxidase (DAO) and histamine methyltransferase (HMNT).

Causes and Factors of Histamine Intolerance

There are several possibilities for the underlying causes of histamine intolerance.  Genetic variants can affect the body’s capacity for breaking down histamine. Imbalances in gut microbes, leaky gut syndrome, and mast cell activation can contribute to increased histamine production. Chronic exposure to allergens or harmful chemicals can also lead to higher histamine levels in the body.

How To Manage Histamines

Taking antihistamines may not be the best solution. Several strategies can help manage histamine intolerance. 

These strategies include addressing nutrient imbalances, such as ensuring sufficient intake of vitamin B6, vitamin C and quercetin, which support histamine regulation. 

Certain supplements like DAO can aid in breaking down histamine. It may also be helpful to follow a low-histamine diet, avoiding high-histamine foods like aged cheeses, fermented foods, and leftovers. 

Additionally, supporting gut health, managing stress, and adopting a healthy lifestyle can contribute to reducing histamine intolerance symptoms.

References:

• Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with
• Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.
• Purchase Dr. Ben Lynch’s Dirty Genes Histamine workbook here.