The Link Between Caffeine Intake and Estrogen Metabolism

Ep 77
This week on ReInvent Healthcare, I bring back a talk I had about caffeine and estrogen. For those who have so many clients who are addicted to caffeine and are unwilling to lessen their caffeine intake, you can show them why it’s important, by explaining this caffeine’s effects on the estrogen metabolism and the inherent risks. Listen to the full episode to find out more.


Caffeine and Breast Cancer
Caffeine’s effect on the body revolves around the enzyme CYP1A2 and its implications on breast cancer risk. The enzyme’s had a significant role in detoxifying caffeine, accounting for approximately 90-95% of its clearance. 

Constant caffeine exposure may divert CYP1A2 from its detoxification function in estrogen metabolism to detecting caffeine, resulting in reduced capacity to detoxify and eliminate  toxic estrogen metabolites. 

This diversion potentially leads to estrogen dominance, which can disrupt hormonal balance and increase the risk of breast and other hormone related cancers.

Genetic variations in the CYP1A2 gene influence caffeine and estrogen metabolism. Individuals with specific genetic profiles may exhibit altered caffeine and estrogen metabolism, warranting a personalized approach in managing caffeine consumption and lifestyle choices.

For individuals with genetic variations, caffeine should be reduced or eliminated to minimize potential health risks associated with estrogen imbalance and breast cancer.

Caffeine’s Effect on Estrogen
Prolonged caffeine exposure diverts CYP1A2 from its primary role in metabolizing estrogens, potentially leading to estrogen dominance, hormonal imbalances, and related health concerns.

The intricate interplay between caffeine and estrogen levels underscores the importance of personalized lifestyle choices, particularly for individuals with specific genetic variations in the CYP1A2 gene.

Chronic caffeine consumption is also linked to increased blood sugar levels, insomnia, acid reflux, and alterations in cortisol production, all of which can disrupt estrogen and progesterone balance. 

Surprisingly, caffeine’s potential cross-reactivity with gluten potentially impacts susceptible individuals and further complicates estrogen-related health outcomes. 

The Gut Microbiome and Estrogen
Certain bacteria in the gut are capable of metabolizing estrogen, specifically by producing an enzyme called β-glucuronidase. This enzyme has the ability to break down estrogen conjugates, which are inactive forms of estrogen, into active and bioavailable estrogen.

The activity of β-glucuronidase can lead to increased levels of estrogen in the body, as the breakdown of conjugated estrogen allows for its reabsorption into circulation. This can potentially impact hormone balance and contribute to various estrogen-related conditions.


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Ritamarie Loscalzo

Dr. Ritamarie Loscalzo is a best-selling author and speaker known for her extensive knowledge, infectious energy, and inspirational message that encourages individuals to become their own best health advocate. She is an internationally recognized nutrition and health authority who specializes in using the wisdom of nature to restore hormone balance with a special emphasis on thyroid, adrenal and insulin imbalances. She founded the Institute of Nutritional Endocrinology to empower health and nutrition practitioners to get to the root cause of health concerns by using functional assessments and natural therapeutics to balance the endocrine system, the body's master controller.

Dr. Ritamarie is a licensed Doctor of Chiropractic with Certification in Acupuncture and is a Diplomat of the American Clinical Nutrition Board. She is a Certified Clinical Nutritionist with a Master’s in Human Nutrition, has completed a 2-year, 500-hour Herbal Medicine Program at David Winston’s Center for Herbal Studies and has a master's degree in Computer Science, which contributes to her skills as an ace problem solver.