Genetics and Epigenetics of Digestion With Steph Jackson

Series 5 Episode 39
In this week's episode of ReInvent Healthcare, we're discussing digestion, and the genetic factors that influence the microbiome. Our guest Steph Jackson is a graduate of our Nutritional Endocrinology Practitioner Training program and is our resident microbiome expert. Steph is an ex yogurt maker, currently called the ‘Gut Whisperer’ by her clients. She advocates using probiotic bacteria functionally in consideration of each and every person's unique biochemistry, in order to achieve optimal health. Tune in to learn how intricately our digestive bacteria is connected to food and overall health and the role our genes play with all of these factors.


  •  [03:00] Is there a higher likelihood of having Celiac or Crohn’s, if testing positive to certain genes?

  • [5:15] FUT2 SNP gene that is responsible for our secretion of H antigen into our mucosa.

  • [10:00] The Bifido bacteria are like the grandmother of all the short chain fatty acid producing bacteria in the large intestine.

  • [12:50] RS 110402, and RS 242924 are the RS numbers to search for when testing for gut stress and IBS. If you test positive for these numbers, the stress you feel is more likely to affect your gut, than someone else without these results.

  • [18:30] AOC1 gene RS 10156191, RS 2052129, RS 1049742. These are RS numbers to search in regards to histamine.

  • [22:00] Many people have mast cell activation and histamine intolerance, and they’re struggling and limiting their diet. There may be another reason why the body is sending out these signals.

  • [30:20] The NLRP3 gene that’s been associated with Crohn’s, colitis, and even celiac disease. RS 10754558 and RS 10733113.
  • [32:00] With the RS 4353135 T variation, there is an increased prevalence of Crohn’s. RS 3806265 C variation, it encodes the making of cryopyrin.


  • Single nucleotide polymorphisms, and the genetic variations can affect the way certain biochemical pathways work for digestion.
  • Due to genetics, stress may affect some people’s gut health more than others.
  • Stress isn’t good in any sense, unless it’s the healthy kind associated with exercise.
  • Risk Alleles
    • RS4353135 with a T variation – Prevalence of Crohn’s disease

    • RS3806265 with a C variation

    • RS10733113 with a GG risk variation



Steph Jackson, ex-yogurt maker now called the Gut Whisperer by her clients, advocates using probiotic bacteria functionally in consideration of your own biochemistry in order to achieve optimal health.  After doing the research to build her non-dairy yogurt company she could not keep quiet about some of the things she discovered and is now using her experience in education and curriculum design to create the Friendly Flora Collective.  If you are fascinated by how intricately our digestive bacteria are connected to our food and our overall health you will enjoy our time together today.

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Ritamarie Loscalzo

Dr. Ritamarie Loscalzo is a best-selling author and speaker known for her extensive knowledge, infectious energy, and inspirational message that encourages individuals to become their own best health advocate. She is an internationally recognized nutrition and health authority who specializes in using the wisdom of nature to restore hormone balance with a special emphasis on thyroid, adrenal and insulin imbalances. She founded the Institute of Nutritional Endocrinology to empower health and nutrition practitioners to get to the root cause of health concerns by using functional assessments and natural therapeutics to balance the endocrine system, the body's master controller.

Dr. Ritamarie is a licensed Doctor of Chiropractic with Certification in Acupuncture and is a Diplomat of the American Clinical Nutrition Board. She is a Certified Clinical Nutritionist with a Master’s in Human Nutrition, has completed a 2-year, 500-hour Herbal Medicine Program at David Winston’s Center for Herbal Studies and has a master's degree in Computer Science, which contributes to her skills as an ace problem solver.